Simple English explanation with example
- It targets a messenger in the body that triggers skin redness.
- It helps stop the immune system from attacking healthy skin cells.
- It reduces the thickness and scaling of psoriasis plaques.
- The medicine works deep in the skin to prevent new flares.
- Example: Silencing a loud alarm that is causing a false panic.
Scientific explanation
- Tremfya (Guselkumab) is a monoclonal antibody targeting Interleukin-23 (IL-23).
- It binds to the p19 subunit to block IL-23 receptor signaling.
- It inhibits the maintenance and expansion of Th17 cell populations.
- This results in decreased levels of IL-17A, IL-17F, and IL-22.
- It effectively modulates the chronic inflammatory response in the dermis.