Simple English explanation with example
- It blocks a specific protein that causes skin and joint inflammation.
- It calms down the immune system to stop it from overreacting.
- It helps clear up the red, scaly patches seen in psoriasis.
- The medicine targets the root cause of swelling in the gut.
- Example: Turning off a faulty sprinkler system that won’t stop spraying.
Scientific explanation
- Skyrizi (Risankizumab) is a humanized IgG1 monoclonal antibody.
- It specifically binds to the p19 subunit of the IL-23 cytokine.
- It inhibits the release of pro-inflammatory cytokines and chemokines.
- This action disrupts the Th17 cell-mediated inflammatory pathway.
- It reduces the excessive keratinocyte proliferation seen in plaque psoriasis.