Simple English explanation with example
- It blocks messengers inside cells that cause painful swelling.
- It acts like a gatekeeper to stop inflammation signals from passing.
- It helps prevent damage to joints and the lining of the gut.
- The medicine works quickly to reduce stiffness and daily pain.
- Example: Cutting the power line to a noisy, disruptive machine.
Scientific explanation
- Rinvoq (Upadacitinib) is a selective Janus kinase (JAK) inhibitor.
- It preferentially inhibits JAK1 over JAK2, JAK3, and TYK2.
- It blocks the phosphorylation and activation of STAT proteins.
- This disrupts the signaling pathway for multiple pro-inflammatory cytokines.
- It modulates the immune response involved in rheumatoid arthritis and Crohn’s.