Simple English explanation with example
- It blocks two proteins that cause the body to itch and swell.
- It calms the underlying inflammation inside the skin and lungs.
- It helps repair the skin barrier to prevent dry, cracked patches.
- It reduces the hyper-sensitive reaction to allergens like dust or pollen.
- Example: Putting a protective shield over a raw, irritated nerve.
Scientific explanation
- Dupixent (Dupilumab) is an interleukin-4 receptor alpha (IL-4Rα) antagonist.
- It inhibits IL-4 and IL-13 signaling by binding to the IL-4Rα subunit.
- This suppresses the Type 2 (Th2) inflammatory response pathway.
- It decreases the release of IgE and inflammatory chemokines in tissues.
- It reduces eosinophilic inflammation in the airways and esophageal lining.