Comparison between Metformin vs Jardiance
| Parameter | Metformin | Jardiance |
|---|---|---|
| Class | Biguanide | SGLT2 inhibitor |
| Mechanism | Reduces glucose production | Glucose excretion |
| Onset | Gradual | Gradual |
| Monitoring | None | None |
| Dosing | BD/TDS | OD |
| Half-life | ~6h | ~12h |
| Reversal Agent | None | None |
| Bleeding Risk | Low | Low |
| Indications | T2DM | T2DM |
| Renal Use | Caution | Avoid low eGFR |
| Pregnancy Use | Avoid | Avoid |
| Drug Interactions | Few | Few |
| Adherence Sensitivity | Moderate | Moderate |
| Best Use Case | First line | CV benefit |
| Cost | Low | High |
| Monitoring Burden | Low | Low |
| Clinical Flexibility | High | Moderate |
| Real-world Convenience | Moderate | High |
| Overall Verdict | First line | Cardio benefit |
| Food Interactions | None | None |