Mebeverine

1. Introduction

Mebeverine is an antispasmodic medicine used to relieve abdominal pain and cramps caused by spasms of the intestinal muscles. It is commonly prescribed for managing irritable bowel syndrome (IBS) and other gastrointestinal conditions. It works by relaxing the smooth muscles in the gastrointestinal tract, thereby reducing discomfort.

2. Indications

  • Irritable bowel syndrome (IBS)
  • Functional bowel disorders with abdominal cramps and spasms
  • Chronic irritable colon conditions

3. Dosage

Adults:

  • 135 mg tablet: One tablet three times a day, 20 minutes before meals.
  • 200 mg modified-release capsule: One capsule twice daily, 20 minutes before breakfast and dinner.

Children:

  • Mebeverine is not generally recommended for children under 10 years of age.

Elderly:

  • No specific dosage adjustment is required; follow adult dosage unless otherwise directed.

4. Administration

  • Take Mebeverine 20 minutes before meals for optimal effect.
  • Swallow tablets or capsules whole with water; do not chew or crush them.

5. Forms Available

  • Tablets: 135 mg
  • Modified-release capsules: 200 mg

6. Side Effects

6.1 Common Side Effects:

  • Nausea
  • Headache
  • Dizziness

6.2 Less Common Side Effects:

  • Indigestion
  • Constipation
  • Dry mouth

6.3 Rare but Serious Side Effects:

  • Allergic reactions, including skin rash, itching, or swelling of the face and throat.

7. Warnings

  • Avoid use in patients with paralytic ileus or severe constipation.
  • Not recommended for children under 10 years of age unless directed by a doctor.

8. Precautions

  • Consult a doctor if symptoms persist or worsen after two weeks of use.
  • Inform your healthcare provider of any allergies, particularly to Mebeverine or similar medicines.

9. Interactions

  • No significant drug interactions have been identified, but consult your doctor if you are taking other medications.
  • No known food or alcohol interactions.

10. Monitoring Parameters

  • Monitor symptoms for improvement or worsening over time.
  • Watch for any signs of allergic reactions.

11. Use in Children

  • Safety and efficacy have not been established in children under 10 years old.

12. Use in Pregnancy

  • Mebeverine should only be used during pregnancy if clearly needed. Consult your healthcare provider before use.

13. Use in Elderly

  • Generally well tolerated; no dose adjustments are necessary unless otherwise directed.

14. Use in Kidney Disease

  • No specific precautions or dose adjustments required, but consult a healthcare provider for advice.

15. Use in Liver Disease

  • Generally safe, but consult your doctor if you have significant liver impairment.

16. Patient Counselling Points

  • Take Mebeverine before meals to maximise effectiveness.
  • Do not skip doses or stop taking the medicine without consulting your doctor.
  • If symptoms persist or worsen after two weeks, seek medical advice.

17. Table of Brand Names, Manufacturer, and Prices in USD

Brand NameManufacturerStrength/Dosage FormPrice (USD)
ColofacAbbott135 mg Tablet$10 (30 tablets)
Colofac MRAbbott200 mg Capsule$12 (30 capsules)
DuspatalinMylan200 mg Capsule$15 (30 capsules)

18. 15 FAQs (Frequently Asked Questions)

1. What is Mebeverine?
Mebeverine is an antispasmodic medicine used to relieve abdominal pain and cramps caused by intestinal spasms.

2. How does Mebeverine work?
Mebeverine works by relaxing the smooth muscles of the gastrointestinal tract, reducing cramps and pain.

3. What is the recommended dosage of Mebeverine?
The usual adult dose is 135 mg three times daily or 200 mg twice daily.

4. Can Mebeverine be taken during pregnancy?
Consult your doctor before use; it should only be used if necessary during pregnancy.

5. Can I take Mebeverine while breastfeeding?
Mebeverine is generally not recommended during breastfeeding unless directed by a doctor.

6. What are the common side effects of Mebeverine?
Common side effects include nausea, headache, and dizziness.

7. Are there any serious risks associated with Mebeverine?
Serious risks are rare but include allergic reactions such as swelling or rash.

8. What should I do if I miss a dose?
Take the missed dose as soon as you remember, unless it is almost time for the next dose.

9. What happens if I overdose on Mebeverine?
Overdose symptoms may include drowsiness or agitation. Seek medical help immediately.

10. Can Mebeverine interact with other medicines?
No significant interactions are known, but always inform your doctor of other medications you are taking.

11. Is Mebeverine safe for children?
It is not recommended for children under 10 years old.

12. Is Mebeverine safe for elderly patients?
Yes, it is generally safe and well-tolerated in older adults.

13. How should Mebeverine be stored?
Store at room temperature in a dry place away from direct sunlight.

14. Do I need a prescription for Mebeverine?
In most regions, Mebeverine requires a prescription.

15. Can Mebeverine be taken with alcohol or specific foods?
There are no known restrictions regarding alcohol or food with Mebeverine.