Simple English explanation with example
- It targets two different proteins involved in the body’s immune response.
- It helps clear skin and calms inflammation in the digestive tract.
- It prevents the cycle of swelling that leads to flare-ups.
- The medicine is given as an injection to provide long-lasting relief.
- Example: Unplugging two different heaters that are making a room hot.
Scientific explanation
- Stelara (Ustekinumab) is a human monoclonal antibody against IL-12 and IL-23.
- It binds to the shared p40 protein subunit of these cytokines.
- It prevents interaction with the IL-12Rβ1 receptor on T cells.
- This inhibits the signaling of Th1 and Th17 inflammatory pathways.
- It reduces the production of IFN-γ and IL-17A in the body.