Simple English explanation with example
- It stops a chemical that makes your blood vessels tight.
- It allows your veins and arteries to relax and widen.
- This makes it easier for the heart to pump blood.
- It helps the kidneys get rid of extra salt and water.
- Example: Widening a narrow garden hose to let water flow easily.
Scientific Explanation
- Lisinopril is an ACE inhibitor (Angiotensin-Converting Enzyme) that prevents vasoconstriction.
- It inhibits the conversion of Angiotensin I to the potent Angiotensin II.
- Reduces aldosterone secretion, leading to decreased sodium and water retention.
- Increases levels of bradykinin, a natural vasodilator, by preventing its degradation.
- Lowers peripheral vascular resistance without increasing heart rate or cardiac output.