Simple English explanation with example
- It blocks a specific protein called IL-17A that causes inflammation.
- It stops the skin from producing too many new cells too fast.
- It reduces joint pain and morning stiffness in the spine.
- It helps prevent long-term damage caused by chronic swelling.
- Example: Putting a cap on a leaking pipe to stop flooding.
Scientific explanation
- Cosentyx (Secukinumab) is a human IgG1 monoclonal antibody.
- It selectively binds to and neutralizes the cytokine interleukin-17A.
- It inhibits the release of pro-inflammatory cytokines and chemokines.
- This prevents the recruitment of neutrophils to the site of inflammation.
- It modulates the immune response in the skin and axial skeleton.