1. Introduction
Benzydamine, commonly marketed under brand names such as Difflam and Tantum Verde, is a non-steroidal anti-inflammatory drug (NSAID) with local analgesic, anti-inflammatory, and antimicrobial properties. It is commonly used as a mouthwash, oral spray, or topical gel for managing pain and inflammation in the mouth, throat, and other areas.
2. Indications
- Approved Indications:
- Relief of pain and inflammation in the mouth and throat (e.g., sore throat, pharyngitis, tonsillitis, oral mucositis).
- Treatment of post-surgical inflammation (e.g., after tonsillectomy or dental procedures).
- Pain relief for oral ulcers.
- Off-Label Uses:
- Symptomatic relief of vaginal inflammation and pain (in topical form).
3. Dosage
- Oral Spray:
- 4–8 sprays every 1.5–3 hours.
- Mouthwash:
- 15 mL diluted with equal parts water, rinse for 30 seconds every 1.5–3 hours.
- Topical Gel:
- Apply a thin layer to the affected area 2–3 times daily.
Dosage may vary based on the condition being treated and the formulation used.
4. Administration
- For the oral spray and mouthwash, do not swallow; rinse or spray directly onto the affected area.
- For topical gel, apply externally to the affected skin or mucous membranes. Avoid application to large areas.
5. Forms Available
- Oral spray: 0.15% w/v.
- Mouthwash: 0.15% w/v solution (150 mg/100 mL).
- Topical gel: 3% w/w.
6. Side Effects
6.1. Common Side Effects
- Oral numbness or tingling.
- Dry mouth.
- Altered taste sensation.
6.2. Less Common Side Effects
- Burning sensation at the site of application.
- Nausea.
6.3. Rare but Serious Side Effects
- Hypersensitivity reactions (e.g., rash, itching, swelling).
- Bronchospasm (in patients with asthma or hypersensitivity).
7. Warnings
- Avoid use in patients with a history of hypersensitivity to benzydamine or other NSAIDs.
- Caution in patients with asthma due to the risk of bronchospasm.
8. Precautions
- Prolonged use (beyond 7 days) is not recommended without medical supervision.
- Avoid contact with eyes; rinse thoroughly with water if accidental contact occurs.
- Do not apply to deep wounds or severely inflamed skin.
9. Interactions
- No significant drug-drug or drug-food interactions reported.
10. Monitoring Parameters
- Symptom relief within a few days of use.
- Watch for signs of hypersensitivity or adverse effects.
11. Use in Children
- Approved for use in children aged 6 years and above (mouthwash and spray).
- Use with caution and under supervision to avoid swallowing the product.
12. Use in Pregnancy
- Limited data on safety in pregnancy.
- Use only if the potential benefit outweighs the risk, particularly in the first trimester.
13. Use in Elderly
- Generally safe, with no specific dosage adjustments required.
14. Use in Kidney Disease
- No specific dosage adjustments required; systemic absorption is minimal.
15. Use in Liver Disease
- No specific dosage adjustments required; systemic absorption is minimal.
16. Patient Counselling Points
- Explain proper use of the formulation (spray, mouthwash, or gel).
- Advise against swallowing the spray or mouthwash.
- Highlight that prolonged use without medical advice is not recommended.
- Inform patients about potential tingling or burning sensations, which are typically mild and temporary.
- Store at room temperature and out of reach of children.
17. Table of Brand Names, Manufacturers, and Prices
Brand Name | Manufacturer | Price (USD) |
---|---|---|
Difflam Spray | Mylan | $10–15 (30 mL) |
Tantum Verde | Angelini Pharma | $10–12 (30 mL) |
Generic Options | Various | $5–10 (30 mL) |
18. FAQs (15 Questions)
- What is benzydamine used for?
It is used to relieve pain and inflammation in the mouth, throat, and other areas. - How does benzydamine work?
It reduces inflammation and provides local analgesic effects. - Can benzydamine be swallowed?
No, it should not be swallowed when used as a mouthwash or spray. - What are the common side effects of benzydamine?
Oral numbness, tingling, and altered taste sensation. - Is benzydamine safe for children?
Yes, for children aged 6 years and above with proper supervision. - Can pregnant women use benzydamine?
Use with caution; consult a doctor before use during pregnancy. - How often can I use benzydamine spray?
It can be used every 1.5–3 hours, up to a maximum of 8 sprays at a time. - Can benzydamine treat oral ulcers?
Yes, it is effective in reducing pain and inflammation associated with oral ulcers. - How should benzydamine mouthwash be used?
Dilute as directed, rinse for 30 seconds, and spit out without swallowing. - Can I use benzydamine for a sore throat?
Yes, it is commonly used to relieve sore throat symptoms. - Does benzydamine interact with other medications?
No significant interactions are reported. - Can benzydamine cause allergies?
Rarely, hypersensitivity reactions may occur. - Is benzydamine effective for post-surgical pain?
Yes, it is often prescribed for pain relief after dental or throat surgeries. - How long does it take for benzydamine to work?
Symptom relief typically occurs within minutes to hours after use. - Do I need a prescription for benzydamine?
In most regions, it is available over-the-counter for short-term use.