Simple English explanation with example
- Helps improve mood by working on two brain pathways
- Used to treat depression
- Can act differently from standard antidepressants
- One part affects signalling, the other helps it last longer
- Like boosting mood through a different route
Scientific explanation
- Contains dextromethorphan and bupropion
- Dextromethorphan modulates NMDA receptor activity and sigma-1 signalling
- Bupropion inhibits CYP2D6 metabolism and prolongs dextromethorphan exposure
- Bupropion also inhibits noradrenaline and dopamine reuptake
- Used for major depressive disorder